Dr. Zhang: Structure and function of metal-binding proteins in bacterial stress response and antibiotic resistance

Biochemistry
Faculty Advisor
Limei Zhang
Contact Email limei.zhang@unl.edu
Advisor College:
Agricultural Sciences and Natural Resources
Potential Student Tasks

Tasks and responsibilities include general lab maintenance and assisting graduate students and postdocs with cloning, expression and purification of proteins from E. coli; data curation and analysis. The student researchers will receive training in experimental documentation and data analysis. Over the long term, the project may expand to learning how to structurally characterize proteins using protein crystallography and single-particle cryo-electron microscopy (cryo-EM).

Student Qualifications

Students are expected to be self-motivated, well organized, willing to work in a fast-paced environment, attentive to detail, and possess an excellent work ethic and desire to improve every day. A curiosity about the structure and function of proteins, as well as a professional interest in biomedical research or biotechnology, is preferred. 

No prior research experience in biochemistry or molecular biology is required. 

Training, Mentoring, and Workplace Community

The undergraduate researchers of this position will work closely with the postdocs and graduate students to actively contribute to cutting-edge research on the molecular basis of the project. All the necessary training will be provided initially. Once training is completed, the undergraduate researchers will be expected to work semi-independently and collaboratively with other group members.  

Many undergraduate students who worked in our lab have co-authored papers in peer-reviewed journals and have been successful in obtaining jobs or receiving offers from professional programs, such as medical school and graduate school. 

Available Positions
1

The Zhang Laboratory is interested in understanding how living organisms utilize metal-bound proteins to respond to stress within the host and develop antibiotic resistance. Owing to their rich electronic properties and reactivity, metals are widely used as cofactors for catalyzing challenging reactions and as adaptors to environmental cues. Knowledge of the structures and functions of these metal-binding proteins will help us understand the molecular mechanisms of infectious diseases and antibiotic resistance and could lead to the design of new bioinspired sensors and catalysts.